Patchoulic alcohol
Patchouli alcohol
CAS: 5986-55-0
Molecular Formula: C15H26O
Patchoulic alcohol - Names and Identifiers
Patchoulic alcohol - Physico-chemical Properties
| Molecular Formula | C15H26O |
| Molar Mass | 222.37 |
| Density | d420 1.0284 |
| Melting Point | 56°; mp (racemate) 39-40° (Danishevsky, Dumas); mp 46-47° (Mirrington, Schmalzl) |
| Boling Point | bp8 140° |
| Specific Rotation(α) | D20 -97.4° (c = 24 in chloroform) |
| Flash Point | 120.2°C |
| Water Solubility | 41.8mg/L at 24℃ |
| Solubility | Almost insoluble in water, soluble in ethanol and ether. |
| Vapor Presure | 0.14Pa at 24℃ |
| Appearance | Hexagonal square quadrangular image crystal |
| Color | White to Off-White Semi-Solid to |
| pKa | 15.23±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | nD65 1.5029 |
| MDL | MFCD14702367 |
| Physical and Chemical Properties | From the dried aerial parts of the patchouli plant |
Patchoulic alcohol - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29061990 |
Patchoulic alcohol - Reference
| Reference Show more | 1. Zhang runjing, Zhu Shuiyan, Shao Yanhua, etc. Study on HPLC fingerprint of patchouli [J]. West China Pharmaceutical Journal, 2016(4):404-407. 2. Wu zhuona, Wu Dongpeng, Hou Jianwei et al. Determination of three volatile components in patchouli from different habitats by GC-FID [J]. Journal of Mathematical Medicine 2017(8). 3. Li Xiaoqi, fan Yanhao, Chen Yang, et al. Simultaneous determination of four components in Patchouli by one-Test multi-evaluation method [J]. Chinese patent medicine 2019(8). 4. Wu Min, Pan Chaomei, Su Jiaxian, Peng Zetong, Cheng can, Dimon. Effect of "sweating" of patchouli on the content of effective components and optimization of "sweating" process [J]. Shi Zhen, National Medicine, 2020,31(05):1116-1119. 5. [IF = 5.81] Xiao Xiaofei et al."The Anti-Diaria Activity of the Non-toxic Dihuang Powder in Mice." Front Pharmacol. 2018 Sep;0:1037 6. [IF = 5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 7. [IF=2.408] Qing-Qing Li et al."Biological Activities of Two Essential Oils from Pogostemon cablin and Eupatorium fortunei and Their Major Components against Fungi Isolated from Panax notoginseng."Chem Biodivers. 2020 Dec;17(12):e2000520 |
Patchoulic alcohol - Reference Information
| LogP | 5.5 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | as the main component of patchouli volatile oil, it is an index component for evaluating the quality of patchouli oil as stipulated in the Pharmacopoeia of the People's Republic of China. At present, gas chromatography is mainly used for the determination of baiqiu Li alcohol in patchouli oil, and the quantitative methods include internal standard method and external standard method. figure: patchouli volatile oil |
| determination method | a method for the determination of the content of baiqiumol in patchouli oil by gas chromatography. Using capillary column DB-5MS (30mm × 0.32, 0.25 μm), N-octaane as internal standard, hydrogen flame ionization detector for detection, internal standard method for quantification. Baiqiu plum alcohol content in the range of 0.2~2.0 mg/mL, baiqiu plum alcohol peak area and internal standard Peak area ratio and baiqiu plum alcohol concentration showed a good linear relationship, correlation coefficient r = 0.9997. The detection limit of the method was 1 μg/mL, the recovery rate was 90.0% ~ 100.6%, and the relative standard deviation was 1.22%(n = 6). The results show that the method is simple, rapid, accurate and reliable, and the precision is better than the external standard method. |
| protective effect of baiqiu plum alcohol on intestinal mucosal barrier in rats with post-infectious irritable bowel syndrome | high-dose baiqiu plum alcohol up-regulates intestinal mucosa by PI-IBS in ZO-1 rats and the expression of occludin, repair damaged epithelial cells; By inhibiting the secretion of IL-1β, promote the secretion of IL-10, improve the intestinal pro-inflammatory/anti-inflammatory factor imbalance. But the protection and regulation of intestinal mucosal barrier is not as good as that of Agastache rugosa. |
| references | [1] Chen Guiqin, Luo Xiang, Li Guisheng, etc. Determination of baiqiu plum alcohol in patchouli oil by gas chromatography [J]. Measurement for chemical analysis, 2013, 29 (6):91-93. [2] Liu Yao, Liu Wei, Yu Linzhong. Protective effect of baiqiu plum alcohol on intestinal mucosal barrier in rats with Postinfectious irritable bowel syndrome [J]. Chinese Journal of clinicians: electronic edition, 2016, 10(20):3047-3052. |
| Use | for content determination/identification/pharmacological experiments. Pharmacological Efficacy: baiqiu plum alcohol on influenza A type 1 Virus, influenza B Virus and avian influenza Virus has obvious inhibition and killing effect. |
Last Update：2024-04-09 15:16:51
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Product Name: Patchouli Alcohol Request for quotation
CAS: 5986-55-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 5986-55-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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